Fecal transplantation—or fecal microbiota transplant (FMT)—can be a hard concept to stomach, but given the procedure’s success and despite recent regulatory interference, it appears to be here to stay. FMT has a nearly 90% cure rate for patients with Clostridium difficile infection, far higher than that of antibiotic therapies. Many initial FMT attempts involved physician- or patient-prepared enemas and colonoscopic transplantations. Thankfully, researchers and industry are developing more palatable and convenient approaches to FMT, including orally administered frozen fecal capsules and stool banks. Therapies aimed at restoring the gut microbiome show promise in numerous other conditions too. Microbial imbalance in the gastrointestinal tract has been implicated in conditions as diverse as diabetes, rheumatoid arthritis, and even disorders of the brain. Both autism and multiple sclerosis have recently been associated with altered gut flora profiles.