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Posted on Jul 28, 2020 |

Bone Marrow Transplant is the cure for Thalassemia

Bone Marrow Transplant is the cure for Thalassemia

Thalassemia is an inherited Genetic condition of Haemoglobin abnormality

Haemoglobin carries oxygen to different parts of the body. It is made of Alfa and Beta chains. There are various types of thalassemia depending on the site of genetic abnormality. The most common types being Alfa Thalassemia and Beta Thalassemia. severity can vary from no symptoms other than mild Anaemia to severe anaemia that requires regular blood transfusions.

These abnormal Haemoglobin cells are more fragile and break down easily. The Body produces more red cells in order to do the function but they are defective.

In India, there are an estimated 10,000 -12,000 new Thalassemia cases diagnosed every year. The higher incidence is due to high consanguineous marriages in India.


Thalassemia Trait or Thalassemia Minor

Means you carry the defective gene but can still make enough red blood cells. So you do not have any symptoms and will only know after doing some blood tests( CBC) which show a slight reduction in Haemoglobin level and small red cell size reflected by reduced MCV on CBC report. Many times these patients are wrongly treated as Iron deficiency with Iron supplements.  If we know the diagnosis we can assess the possibility of their children having Thalassemia major by receiving double dose faulty genes if her partner or husband also has Thalassemia minor.


Symptomatic Thalassemia: Thalassemia Major

There is more than one gene abnormality and most of the Haemoglobin produced is faulty and they become severely anaemic by 6 months of age and will need frequent blood transfusions.

These children need blood transfusions every few weeks or months for their life. This causes excess iron accumulation in the liver and heart and damage of organs leads to reduced life span. Repeated blood transfusions also pose risk for transfusion-transmitted infections like Hepatitis B and Hepatitis C. Their growth and development are also affected by this.

These patients need treatment for reducing iron overload called iron chelation, which is an expensive treatment and is not easily available for most of our patients.



Bone Marrow Transplantation is a cure for these patients. The earlier the transplant is done the better the outcome. But unfortunately, very few patients avail of this treatment due to lack of awareness and the cost.

If we calculate the cost of life long transfusions, Iron chelation, patient and family time spent in hospitals for transfusions and risk of viral infections we still believe Bone marrow Transplant is cost-effective on long run. We are offering the services at Apollo Hyderabad and few other hospitals in Hyderabad and all our patients do not need to travel all the way to Vellore.

Many advanced countries like England offer antenatal thalassemia screening blood test for all pregnant ladies.

We need to adopt universal thalassemia screening in all pregnant ladies to predict risk in newborn and adopt antenatal diagnosis if required.  Early referral for Bone Marrow Transplant, which is the only option to cure this. Safe blood transfusions and early initiation of Iron chelation is the key to success.



Dr Padmaja Lokireddy

MD, MRCP, FRCPath(Haematology)

Consultant Haemato oncology and Stem cell Transplant

Apollo Health City, Jubilee Hills, Hyderabad, India