Anti Endomysium, Reticulin & Gliadin-IgA
Indirect Immunofluorescence method Biochip Titerplane Technique Anti Endomycium Anti Gliadin Anti Endomycium Anti Endomysium, Reticulin & Gliadin-IgA Primate intestine Gliadin coated chip Primate Liver section
Clinical Significance
Determination of IgA antibodies against Endomysium ,Reticulin and Gliadin provides confirmation of clinical diagnosis of gluten-sensitive enteropathy(small children :coeliac disease,adults:non-tropical sprue).Reticulin antibodies are found in 60% of celiac disease patients. Endomysium antibodies possess a higher specificity and is used as means of determining the predisposition for gluten sensitive enteropathy among relatives of patients with coeliac disease.
Determination of antibodies against gliadin is also suitable for monitoring the course of therapy or a gluten loading test and for asessing the compliance of a gluten-free diet. Usually endomycium and gliadin antibodies occur together however,they are not identical and may not correlate with each other in all cases.
Some patients with gluten-sensitive enteropathy also suffer from Duhring’s dermatitis herpetiformis, a chronic skin disease connected with the formation of blisters.This disease can also appear by itself.
